Children, adolescents, and young adults up to 24 years old who take antidepressant drugs have an increased risk of suicidal thoughts and behavior. All patients on antidepressant medications should be carefully monitored. Pristiq is an SNRI antidepressant.
Pristiq treats depression in adults. The generic name is desvenlafaxine. Effexor is also an SNRI antidepressant. Effexor treats depression in adults.
Effexor XR extended-release treats depression, social anxiety disorder, panic disorder, and generalized anxiety disorder. The generic name of Effexor is venlafaxine. The medications are very similar. When Effexor is metabolized in the body, it turns into desvenlafaxine, the active ingredient of Pristiq. The two drugs are similar but have some differences, such as in dose, price, side effect rates of occurrence, and drug interactions.
Both drugs are similar in terms of efficacy. Your healthcare provider can guide you regarding which drug may be appropriate for you. Consult your healthcare provider for advice. He or she will weigh the benefits of taking an antidepressant vs.
Neonates exposed to certain antidepressants, including SNRIs or SSRIs selective serotonin reuptake inhibitors like Prozac , in the third trimester of pregnancy, have developed serious complications.
Pristiq or Effexor should not be taken with alcohol because the combination may increase the risk of respiratory depression slowed breathing, not getting enough oxygen and increase sedation and drowsiness, and impair alertness. The combination can also worsen anxiety and depression.
Although Pristiq is only indicated to treat depression, some doctors prescribe it off-label for anxiety. Some people need to try different medications to see which works best. Consult your healthcare provider for more information. Drugs classified as mood stabilizers are usually used to treat bipolar disorder. Pristiq is indicated to treat depression. Taking Pristiq may make your mood feel more stable, but it is not classified as a mood stabilizer.
Effexor venlafaxine is an SNRI. Skip to main content Search for a topic or drug. The present study does have some limitations. First, it is a short-term study with less number of patients andeffect of small sample size cannot be ruled out on results of the study. The present study demonstrated almost similar efficacy and safety in reducing depression and anxiety with both escitalopram and desvenlafaxine, but clinical superiority of one drug over the other cannot be definitely be concluded due to small sample size.
Escitalopram and desvenlafaxine were well-tolerated. National Center for Biotechnology Information , U. Journal List Perspect Clin Res v.
Perspect Clin Res. Brij Mohan Gupta , Samir H. Zargar , Manu Arora , 1 and Vishal R. Samir H. Vishal R. Author information Copyright and License information Disclaimer.
Address for correspondence: Dr. E-mail: moc. This article has been cited by other articles in PMC. Abstract Aim and Objective: To compare efficacy and safety of escitalopram with desvenlafaxine in the treatment of major depression. Materials and Methods: A total of 60 patients of depression were randomized into two groups after meeting inclusion criterion.
Conclusion: The present study demonstrated similar efficacy and safety in reducing depression and anxiety with both escitalopram and desvenlafaxine, but clinical superiority of one drug over the other cannot be concluded due to limitations of the small sample size.
Key words: Anxiety, desvenlafaxine, escitalopram, major depression. Open in a separate window. Figure 1. Statistical analysis All the analysis was carried out with the help of computer software SPSS version 15 for windows. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest. Alternative projections of mortality and disability by cause Global Burden of Disease Study.
CNS Drugs. Safety and tolerability considerations: Tricyclic antidepressants vs selective serotonin reuptake inhibitors. Acta Psychiatr Scand Suppl. Washington: American Psychiatry Association; Hamilton M. A rating for depression. J Neurol Neurosurg Psychiatry. Fixed-dose trial of the single isomer SSRI escitalopram in depressed outpatients. J Clin Psychiatry. Int Clin Psychopharmacol. Escitalopram continuation treatment prevents relapse of depressive episodes.
A double blind placebo-controlled study of the efficacy and safety of desvenlafaxine succinate in the treatment of major depressive disorder. A randomized, double-blind, placebo-controlled trial of desvenlafaxine succinate in the treatment of major depressive disorder. These side effects include:. Drinking alcohol can also make your depression symptoms worse. Other drugs are available that can treat major depressive disorder. Some may be better suited for you than others.
Other SNRIs and drugs from other classes of medications are also available to treat depression. They can tell you about other medications that may work well for you. You may wonder how Pristiq compares to other medications that are prescribed for similar uses. Here we look at how Pristiq and Effexor XR are alike and different. Pristiq contains desvenlafaxine, while Effexor XR contains venlafaxine.
Both drugs belong to a class of antidepressants called serotonin-norepinephrine reuptake inhibitors SNRIs. A class of medications is a group of drugs that work in a similar way in your body. Desvenlafaxine and venlafaxine are closely related. Venlafaxine the drug in Effexor XR is metabolized broken down by your liver. Desvenlafaxine is known as an active metabolite of venlafaxine. When you take venlafaxine, most of the antidepressant effect in your body is actually produced by desvenlafaxine.
MDD is often called depression. Pristiq is taken by mouth once daily. It should be swallowed whole, and it can be taken with or without food. Effexor XR comes as extended-release capsules. Effexor XR is taken by mouth once each day. Effexor XR capsules can be swallowed whole. Or the capsules can be opened and sprinkled onto a spoonful of applesauce. The applesauce should then be swallowed without chewing, followed by drinking a glass of water to make sure the drug is completely swallowed.
With either option, Effexor XR should be taken with food. Pristiq and Effexor XR are closely related. Therefore, both medications can cause very similar side effects. Below are examples of these side effects. One review of clinical studies found that, in general, these two drugs had similar effectiveness for treating depression. Pristiq and Effexor XR are both brand-name drugs. There are generic forms of both drugs available.
Brand-name medications usually cost more than generics. According to estimates on GoodRx. Here we look at how Pristiq and Cymbalta are alike and different. Pristiq contains desvenlafaxine, while Cymbalta contains duloxetine. Pristiq is taken by mouth each day.
It can be taken with or without food. Cymbalta comes as delayed-release capsules. Cymbalta capsules are typically taken once or twice a day. They can be taken with or without food. Pristiq and Cymbalta are both from the same class of drugs. These lists contain examples of serious side effects that can occur with Pristiq, with Cymbalta, or with both drugs when taken individually.
But separate studies have found both Pristiq and Cymbalta to be effective for treating depression. Pristiq and Cymbalta are both brand-name drugs.
There generic forms of both drugs available. You can also call the American Association of Poison Control Centers at or use their online tool. But if your symptoms are severe, call or go to the nearest emergency room right away. Pristiq can interact with several other medications. It can also interact with certain supplements. Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works.
Other interactions can increase side effects or make them more severe. Below are lists of medications that can interact with Pristiq.
These lists do not contain all the drugs that may interact with Pristiq. Before taking Pristiq, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Taking Pristiq with these drugs increases your risk of a serious side effect called serotonin syndrome. This is a dangerous condition caused by high levels of a brain chemical called serotonin in your body. Pristiq, linezolid, and methylene blue can all raise your level of serotonin.
When these drugs are taken together, your level of serotonin may be raised even higher. Your doctor will monitor you closely for signs of serotonin syndrome.
You can start taking Pristiq again 24 hours after your last dose of linezolid or methylene blue. Taking Pristiq with a monoamine oxidase inhibitor MAOI increases your risk of a serious side effect called serotonin syndrome. This is a dangerous condition caused by having high levels of a brain chemical called serotonin in your body. MAOIs are a class of antidepressants. A class of drugs is a group of medications that act in a similar way. MAOIs and Pristiq both increase levels of serotonin in your body.
Taking Pristiq with certain other antidepressants can increase your risk of serotonin syndrome. Pristiq and certain other antidepressants all work by raising your levels of serotonin. Examples of other antidepressants that can increase your risk of serotonin syndrome if taken with Pristiq include the following.
Taking Pristiq with lithium Lithobid can increase your risk of serotonin syndrome. This is a dangerous condition that results when levels of a brain chemical called serotonin get too high in your body. Pristiq and lithium both increase your levels of serotonin. They may recommend different treatment options for you. Taking Pristiq with buspirone can increase your risk of serotonin syndrome. This is a dangerous condition that results from high levels of a brain chemical called serotonin inside your body.
Both Pristiq and buspirone can increase your levels of serotonin. They may recommend that you take a different drug to treat your anxiety. Taking triptan medications with Pristiq could increase your risk of a serious side effect called serotonin syndrome. This is a dangerous condition that occurs when levels of a brain chemical called serotonin get too high in your body. Triptan medications and Pristiq both increase your levels of serotonin.
Triptan medications are used to treat migraine and cluster headaches. Examples of triptan medications that increase your risk for serotonin syndrome if taken with Pristiq include:.
They may recommend that you take a different drug to treat your headaches. Taking tramadol ConZip, Ultram or fentanyl Duragesic, Subsys, Actiq, others with Pristiq increases your risk of serious side effect called serotonin syndrome. Pristiq, fentanyl, and tramadol can all increase your serotonin levels. Tramadol and fentanyl are used to treat pain. They may switch you to a different medication to treat your pain.
Taking amphetamine drugs, including Adderall , with Pristiq increases your risk of a serious side effect called serotonin syndrome. Both amphetamines and Pristiq can increase your serotonin levels. Examples of amphetamine drugs that increase your risk of serotonin syndrome if taken with Pristiq include:.
Taking these drugs together particularly increases your risk of bleeding in your stomach and intestines. You should call your doctor right away if you have any blood in your vomit or stools. Anticoagulant drugs are taken to treat or prevent blood clots. Taking Pristiq with an anticoagulant drug can increase your risk of bleeding problems. Examples of anticoagulant drugs that increase your risk of bleeding problems if taken with Pristiq include:.
Tell your doctor right away if you have any unusual bruising or bleeding. If you take a diuretic medication with Pristiq, you may have a higher risk of hyponatremia low level of sodium in your blood.
Diuretic medications help your body to lose excess fluid. These drugs can sometimes cause your sodium level to drop. Pristiq can also have this effect in your body. You may need blood tests to monitor your sodium level. Also, be sure to tell your doctor if you have any symptoms of low blood sodium. Certain herbs and supplements may interact with Pristiq. Taking this herb with Pristiq raises your risk of a serious side effect called serotonin syndrome.
Serotonin syndrome is a dangerous condition that can occur if levels of a brain chemical called serotonin get too high in your body. Both St. Doing this increases your risk of a serious side effect called serotonin syndrome. This is a dangerous condition that occurs if levels of a brain chemical called serotonin get too high in your body.
Both tryptophan and Pristiq can raise your serotonin levels. Taking Pristiq improves your depression symptoms over a period of time and helps you get back to feeling like your old self.
Controlled substances are drugs that are prescribed and dispensed under federal laws. These laws help ensure that certain drugs are safely given to people because these drugs can sometimes be misused.
However, if you find that Pristiq makes you feel sleepy, taking Xanax will likely make this worse. The shell outer covering of Pristiq tablets can pass through your digestive tract without being digested broken down. However, there have been studies looking at a very similar antidepressant called venlafaxine when taken by pregnant women. Venlafaxine is metabolized broken down by your liver. One of the chemicals made in this process is called desvenlafaxine.
This chemical is the active drug in Pristiq.
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